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Differences in Restylane, Juvederm, and Perlane

restylane perlane juvederm differencesThe amount of information about aesthetic medical injectables available to us can feel overwhelming. Let us put it simply. Have you wanted to eliminate wrinkles, smooth your skin, or add volume to your lips? If the answer is yes and you’ve done your research, you’ve come across information about injectable dermal fillers. Hearing the types of fillers offered, you may wonder about Restylane, Juvederm, and Perlane differences.

How Dermal Fillers Work

Dermal fillers are an injectable gel, administered with a tiny needle. Fillers are a non-invasive, non-surgical, and very popular way to receive maximum age-defying results without going through invasive surgeries. All injectable treatments are roughly 15 minutes to an hour, require little to no downtime, and side effects are generally mild. Each injection explained below works to revitalize and pump up the volume, boosting your skin’s natural supply of hyaluronic acid. In return, leaving you looking and feeling refreshed and revitalized.

Restylane Filler

Restylane is the original filler, first to be approved by the FDA, and the first of its kind as a hyaluronic acid-based facial filler. Restylane is most commonly used for lip injections but as other fillers, it can be used to smooth wrinkles and fill deep creases.

Juvederm Filler

Juvederm is the most popular and widely used facial filler. Similar to Restylane, it’s also a hyaluronic acid-based injectable. Juvederm is primarily used for contouring the face in the cheeks and around the mouth to reverse the signs of aging, although it’s also a popular lip filler. Juvederm has a family of fillers that are all specified to certain areas of the body.

Perlane Filler

Perlane is a part of the Restylane line. However, Perlane is three times thicker than other injectables. As a result, it was manufactured to be injected into tougher areas of the body.


In general, there isn’t much of a difference between the three injectable fillers. Every filler mentioned above contains hyaluronic acid and they all have the same effect. There are some key areas that Restylane, Juvederm, and Perlane differences are distinct.

  • Some include lidocaine, some do not.
  • Many patients claim Juvederm works better for under-eye treatments
  • Many patients claim Restylane works better for lip injections
  • Perlane is better for areas where skin is leaner and thin
  • Juvederm can last anywhere from 1-2 years
  • Restylane can last anywhere from 6-18 months
  • Perlane can last 6 months on average

Common Side Effects

Discuss any and all prior facial cosmetic procedures with your service provider before treatment. Be sure your injector explains all rare, but sometimes serious, side effects with you prior to your appointment. Common side effects typically subside days after treatment and are typically mild, these include:

  • Bruising, bleeding, redness or pain near the injection site
  • Skin irritation or rash
  • Swelling
  • Skin damage or infection
  • Lumps and bumps under the skin

Dermal Fillers Injections

There are areas where fillers are not the best option to use. Speak to your service provider if you are looking to smooth your forehead and areas near the eye or nose. Your injector can recommend other injectable treatments safe for these areas. Dermal fillers work best in these areas:

  • Smoothing lines near the mouth
  • Eliminating vertical lip lines
  • Chin creases
  • Plumping the lips
  • Adding volume to the cheeks

Interested in learning more about Restylane, Juvederm, and Perlane differences? We offer your choice of virtual consultations from the comfort of your home or in-person complimentary consults. Click here to schedule yours!